Mitchell Froom started his career as a session player noted for his keyboard ability. He released his solo debut "The Key of Cool" in 1984. His breakthrough as producer was Crowded House's self-titled debut. From 1992 to 2002 Froom had a partnership with the engineer Tchad Blake, that lasted over his period with Suzanne Vegan, and resulted in Mitchell Froom's second album "Dopamine" (1998). Froom released "A Thousand Days" in 2005.

As a session musician, or producer, Froom worked with Peter Case, Richard Thompson, Paul McCartney, Neil Finn, Tim Finn, The Crowded House, Maria McKee, Los Lobos, Cibo Matto, Ron Sexsmith, Elvis Costello, The Corrs, Laurie Anderson, Sheryl Crow, The Del Fuegos, Peter Gabriel, Latin Playboys, Randy Newman, Roy Orbison, Pearl Jam, Joan Osborne, Tom Petty, Bonnie Raitt, Vonda Shepard, Rick Springfield, Michelle Shocked.

Mitchell Froom started collaborating with Suzanne Vega when he was chosen to produce Suzanne's fourth album: "99.9°F" (1992). Froom played some instruments in the album, and toured in the Suzanne Vega band from April 1993.

In 1996, then married with Suzanne Vega, he produced "Nine Objects of Desire", and toured again from late 1996 to 1997. In 1998 Mitchell Froom would still produce 2 more songs to be included in the compilation "Tried And True".